Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial.

ABSTRACT: The geroscience hypothesis proposes that therapy to slow or reverse molecular changes that occur with aging can delay or prevent multiple chronic diseases and extend healthy lifespan^1-3. Caloric restriction (CR), defined as lessening caloric intake without depriving essential nutrients⁴, results in changes in molecular processes that have been associated with aging, including DNA methylation (DNAm)^5-7, and is established to increase healthy lifespan in multiple species^8,9. Here we report the results of a post hoc analysis of the influence of CR on DNAm measures of aging in blood samples from the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) trial, a randomized controlled trial in which n = 220 adults without

SUBMITTER: Waziry R 

PROVIDER: S-EPMC10148951 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature