Functional genomics in stroke: current and future applications of iPSCs and gene editing to dissect the function of risk variants.

ABSTRACT: Stroke is an important disease with unmet clinical need. To uncover novel paths for treatment, it is of critical importance to develop relevant laboratory models that may help to shed light on the pathophysiological mechanisms of stroke. Induced pluripotent stem cells (iPSCs) technology has enormous potential to advance our knowledge into stroke by creating novel human models for research and therapeutic testing. iPSCs models generated from patients with specific stroke types and specific genetic predisposition in combination with other state of art technologies including genome editing, multi-omics, 3D system, libraries screening, offer the opportunity to investigate disease-related pathways and identify potential novel therapeutic targets that can then be tested in these models. Thus, iP

SUBMITTER: Granata A 

PROVIDER: S-EPMC10148993 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature