Reactive metabolic byproducts contribute to antibiotic lethality under anaerobic conditions.
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ABSTRACT:
SUBMITTER: Wong F
PROVIDER: S-EPMC10149100 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
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Reactive metabolic byproducts contribute to antibiotic lethality under anaerobic conditions.
Wong Felix F Stokes Jonathan M JM Bening Sarah C SC Vidoudez Charles C Trauger Sunia A SA Collins James J JJ
Molecular cell 20220815 18
Understanding how bactericidal antibiotics kill bacteria remains an open question. Previous work has proposed that primary drug-target corruption leads to increased energetic demands, resulting in the generation of reactive metabolic byproducts (RMBs), particularly reactive oxygen species, that contribute to antibiotic-induced cell death. Studies have challenged this hypothesis by pointing to antibiotic lethality under anaerobic conditions. Here, we show that treatment of Escherichia coli with b ...[more]
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