Sensing ultrasound localization microscopy for the visualization of glomeruli in living rats and humans.

ABSTRACT:

Background

Estimation of glomerular function is necessary to diagnose kidney diseases. However, the study of glomeruli in the clinic is currently done indirectly through urine and blood tests. A recent imaging technique called Ultrasound Localization Microscopy (ULM) has appeared. It is based on the ability to record continuous movements of individual microbubbles in the bloodstream. Although ULM improved the resolution of vascular imaging up to tenfold, the imaging of the smallest vessels had yet to be reported.

Methods

We acquired ultrasound sequences from living humans and rats and then applied filters to divide the data set into slow-moving and fast-moving microbubbles. We performed a double tracking to highlight and characterize populations of microbubbles with singular

SUBMITTER: Denis L 

PROVIDER: S-EPMC10149190 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature