Periostin Protects Against Alcohol-related Liver Disease by Activating Autophagy by Interacting With Protein Disulfide Isomerase.

ABSTRACT:

Background & aims

The matricellular protein periostin plays a critical role in liver inflammation, fibrosis, and even carcinoma. Here, the biological function of periostin in alcohol-related liver disease (ALD) was investigated.

Methods

We used wild-type (WT), Postn-null (Postn^-/-) mice and Postn^-/- mice with periostin recovery to investigate the biological function of periostin in ALD. Proximity-dependent biotin identification analysis identified the protein that interacted with periostin, and coimmunoprecipitation analysis validated the interaction between protein disulfide isomerase (PDI) and periostin. Pharmacological intervention and genetic knockdown of PDI were used to investigate the functional correlation between periostin and PDI in ALD develo

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10149225 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature