Gut Microbiota Remodeling and Intestinal Adaptation to Lipid Malabsorption After Enteroendocrine Cell Loss in Adult Mice.

ABSTRACT:

Background & aims

Enteroendocrine cells (EECs) and their hormones are essential regulators of whole-body energy homeostasis. EECs sense luminal nutrients and microbial metabolites and subsequently secrete various hormones acting locally or at a distance. Impaired development of EECs during embryogenesis is life-threatening in newborn mice and humans due to compromised nutrient absorption. However, the physiological importance of the EEC system in adult mice has yet to be directedly studied. Herein, we aimed to determine the long-term consequences of a total loss of EECs in healthy adults on energy metabolism, intestinal transcriptome, and microbiota.

Methods

We depleted intestinal EECs by tamoxifen treatment of adult Neurog3^fl/fl; Villin-CreER^T2 male mi

SUBMITTER: Blot F 

PROVIDER: S-EPMC10149283 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature