The impact of HIV on non-adherence for tamoxifen among women with breast cancer in South Africa.

ABSTRACT:

Purpose

Women living with HIV (WLWH) and breast cancer (BC) have worse overall survival than HIV-negative women with BC, and poor adherence to prescribed tamoxifen is known to contribute to poor survival. We therefore investigated the association of HIV infection with adherence to adjuvant tamoxifen among women with localized hormone receptor (HR)-positive breast cancer in South Africa.

Methods

Among 4,097 women diagnosed with breast cancer at six hospitals in the prospective South African Breast Cancer and HIV Outcomes (SABCHO) cohort study between July 2015 and December 2020, we focused on black women with stages I-III HR-positive breast cancer who were prescribed 20 mg of adjuvant tamoxifen daily. We collected venous blood once from each participant during a routine clini

SUBMITTER: Ayeni OA 

PROVIDER: S-EPMC10149344 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature