Intestinal Reg4 deficiency confers susceptibility to high-fat diet-induced liver steatosis by increasing intestinal fat absorption in mice.

ABSTRACT:

Background & aims

Regenerating gene family member 4 (REG4) is a novel marker for enteroendocrine cells and is selectively expressed in specialised enteroendocrine cells of the small intestine. However, the exact roles of REG4 are largely unknown. In this study we investigate the effects of REG4 on the development of dietary fat-dependent liver steatosis and the mechanisms involved.

Methods

Mice with intestinal-specific Reg4 deficiency (Reg4 ^ΔIEC ) and Reg4-floxed alleles (Reg4 ^fl/fl ) were generated to investigate the effects of Reg4 on diet-induced obesity and liver steatosis. Serum levels of REG4 were also measured in children with obesity using ELISA.

Results

Reg4 ^ΔIEC mice fed

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10149362 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature