Functional brain changes in sarcopenia: evidence for differential central neural mechanisms in dynapenic older women.

ABSTRACT:

Background

The European Working Group on Sarcopenia in Older People (EWGSOP2) recently revised its definition and diagnostic criteria for sarcopenia, placing muscle strength at the forefront. The pathogenesis of dynapenia (or low muscle strength) is still not fully understood, but there is emerging evidence that central neural factors constitute critical determinants.

Methods

Our cross-sectional study included 59 community-dwelling older women (mean age 73.1 ± 4.9 years). Participants underwent detailed skeletal muscle assessments for muscle strength defined by handgrip strength and chair rise time measurements using the recently published EWGSOP2 cut-off points. Functional magnetic resonance imaging (fMRI) was assessed during the performance of a cognitive dual-task paradig

SUBMITTER: Trost W 

PROVIDER: S-EPMC10149465 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature