Biliatresone: progress in biliary atresia study.

ABSTRACT:

Background

Biliary atresia (BA) is one of the main causes of neonatal end-stage liver disease. Without timely diagnosis and treatment, most children with BA will develop irreversible liver fibrosis within the first two months. While current theorized causes of BA include viral infection, immune disorders, and genetic defects, the comprehensive etiology is still largely unknown. Recently, biliatresone attracted much interest for its ability to induce BA in both zebrafish and mice, so we summarized the latest progress of biliatresone research in BA and tried to answer the question of whether it could provide further clues to the etiology of human BA.

Data sources

We conducted a PubMed search for any published articles related to the topic using search terms including "biliary

SUBMITTER: Zhu JJ 

PROVIDER: S-EPMC10149470 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature