Metabolic Acidosis and Adverse Outcomes and Costs in CKD: An Observational Cohort Study.

ABSTRACT:

Rationale & objective

Metabolic acidosis is a risk factor for progression of chronic kidney disease (CKD), but little is known about its effect on health care costs and resource utilization. We describe the associations between metabolic acidosis, adverse kidney outcomes, and health care costs in patients with CKD stages G3-G5 and not receiving dialysis.

Study design

Retrospective cohort study.

Setting & participants

An integrated claims-clinical data set of US patients with CKD stages G3-G5, with serum bicarbonate values of 12 to <22 mEq/L (metabolic acidosis group) or 22 to 29 mEq/L (normal serum bicarbonate level group).

Predictor

The primary exposure variable was the baseline serum bicarbonate level.

Outcomes

The primary clinical outcome was the comp

SUBMITTER: Reaven NL 

PROVIDER: S-EPMC10149501 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature