PET/CT imaging 2 h after injection of [¹⁸F]PSMA-1007 can lead to higher staging of prostate cancer than imaging after 1 h.

ABSTRACT:

Background

[¹⁸F]PSMA-1007 is a prostate specific membrane antigen (PSMA) ligand for positron emission tomography (PET) imaging of prostate cancer. Current guidelines recommend imaging 90-120 min after injection but strong data about optimal timing is lacking. Our aim was to study whether imaging after 1 h and 2 h leads to a different number of detected lesions, with a specific focus on lesions that might lead to a change in treatment.

Methods

195 patients underwent PET with computed tomography imaging 1 and 2 h after injection of [¹⁸F]PSMA-1007. Three readers assessed the status of the prostate or prostate bed and suspected metastases. We analyzed the location and number of found metastases to determine N- and M-stage of patients. We also analyzed stand

SUBMITTER: Hvittfeldt E 

PROVIDER: S-EPMC10149540 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature