The efficacy and safety of buprenorphine for the treatment of depression: A systematic review and meta-analysis.

ABSTRACT:

Background

Depressive disorders are common. Many patients with major depression do not achieve remission with available treatments. Buprenorphine has been raised as a potential treatment for depression as well as suicidal behavior but may pose certain risks.

Methods

A meta-analysis comparing the efficacy, tolerability, and safety of buprenorphine (or combinations such as buprenorphine/samidorphan) versus control in improving symptoms in patients with depression. Medline, Cochrane Database, PsycINFO, Excerpta Medica Database and The Cumulative Index to Nursing and Allied Health Literature were searched from inception through January 2, 2022. Depressive symptoms were pooled using Hedge's g with 95% Confidence Intervals (CI). Tolerability, safety, suicide outcomes were summariz

SUBMITTER: Riblet NB 

PROVIDER: S-EPMC10149594 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature