Alcohol-induced changes in mesostriatal resting-state functional connectivity are linked to sensation seeking in young adults.

ABSTRACT:

Background

Studies in animals and humans suggest that greater levels of sensation seeking and alcohol use are related to individual differences in drug-induced dopamine release. However, it remains unclear whether drug-induced alterations in the functional synchrony between mesostriatal regions are related to sensation seeking and alcohol use.

Methods

In this within-subject masked-design study, 21-year-old participants (n = 34) underwent functional magnetic resonance imaging to measure ventral tegmental area (VTA) resting-state functional connectivity to the striatum after receiving alcohol (target blood alcohol concentration 0.08 g/dL) or placebo. Participants also completed the UPPS-P Impulsive Behavior Scale to assess sensation seeking, the Young Adult Alcohol Consequence

SUBMITTER: Morales AM 

PROVIDER: S-EPMC10149605 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature