Regulatory mechanism of trichothecene biosynthesis in Fusarium graminearum.

ABSTRACT: Among the genes involved in the biosynthesis of trichothecene (Tri genes), Tri6 and Tri10 encode a transcription factor with unique Cys₂His₂ zinc finger domains and a regulatory protein with no consensus DNA-binding sequences, respectively. Although various chemical factors, such as nitrogen nutrients, medium pH, and certain oligosaccharides, are known to influence trichothecene biosynthesis in Fusarium graminearum, the transcriptional regulatory mechanism of Tri6 and Tri10 genes is poorly understood. Particularly, culture medium pH is a major regulator in trichothecene biosynthesis in F. graminearum, but it is susceptible to metabolic changes posed by nutritional and genetic factors. Hence, appropriate precautions shou

SUBMITTER: Liew MXX 

PROVIDER: S-EPMC10149712 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature