Functional connectivity changes are correlated with sleep improvement in chronic insomnia patients after rTMS treatment.

ABSTRACT:

Background

Repetitive transcranial magnetic stimulation (rTMS) has been increasingly used as a treatment modality for chronic insomnia disorder (CID). However, our understanding of the mechanisms underlying the efficacy of rTMS is limited.

Objective

This study aimed to investigate rTMS-induced alterations in resting-state functional connectivity and to find potential connectivity biomarkers for predicting and tracking clinical outcomes after rTMS.

Methods

Thirty-seven patients with CID received a 10-session low frequency rTMS treatment applied to the right dorsolateral prefrontal cortex. Before and after treatment, the patients underwent resting-state electroencephalography recordings and a sleep quality assessment using the Pittsburgh Sleep Quality Index (PSQI).

R

SUBMITTER: Zhu L 

PROVIDER: S-EPMC10149758 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature