Self-assembled multifunctional nanotheranostics against circulating tumor clusters in metastatic breast cancer.

ABSTRACT: Circulating tumor clusters (CTC) disseminating from the primary tumor are responsible for secondary tumor formation where the conventional treatments such as chemotherapy and radiotherapy does not prevent the metastasis at locally advanced stage of breast cancer. In this study, a smart nanotheranostic system has been developed to track and eliminate the CTCs before it can colonize at a new site, which would reduce metastatic progression and increase the five-year survival rate of the breast cancer patients. Targeted multiresponsive (magnetic hyperthermia and pH) nanomicelles incorporated with NIR fluorescent superparamagnetic iron oxide nanoparticles were developed based on self-assembly for dual modal imaging and dual toxicity for spontaneous killing of CTCs in blood stream. A heterogenou

SUBMITTER: Dhandapani R 

PROVIDER: S-EPMC10149900 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature