Sensory impairment and beta-amyloid deposition in the Baltimore longitudinal study of aging.

ABSTRACT:

Introduction

Beta-amyloid (Aβ) plaque deposition is a biomarker of preclinical Alzheimer's disease (AD). Impairments in sensory function are associated with cognitive decline. We sought to investigate the relationship between PET-indicated Aβ deposition and sensory impairment.

Methods

Using data from 174 participants ≥55 years in the Baltimore Longitudinal Study of Aging, we analyzed associations between sensory impairments and Aβ deposition measured by PET and Pittsburgh Compound B (PiB) mean cortical distribution volume ratio (cDVR).

Results

The combinations of hearing and proprioceptive impairment and hearing, vision, and proprioceptive impairment, were positively correlated with cDVR (β = 0.087 and p = 0.036, β = 0.110 and p = 0.018, re

SUBMITTER: Yesantharao L 

PROVIDER: S-EPMC10150164 | biostudies-literature | 2023 Apr-Jun

REPOSITORIES: biostudies-literature