Novel histologic score predicts recurrent intestinal metaplasia after successful endoscopic eradication therapy.

ABSTRACT: Endoscopic eradication therapy (EET) is an effective treatment for Barrett's esophagus (BE); however, disease recurrence remains problematic requiring surveillance post-treatment. While data regarding predictors of recurrence are limited, uncontrolled reflux may play a significant role. Our aim was to develop a scoring system based on histopathologic reflux in surveillance biopsies following EET to identify patients at high risk for recurrence of BE. Patients were identified from two centers in the treatment with resection and endoscopic ablation techniques for BE consortium. Hematoxylin and eosin-stained slides of surveillance biopsies post-EET were assessed for histologic changes associated with reflux from a cohort of patients who also underwent pH-metry (derivation cohort). We develope

SUBMITTER: Triggs JR 

PROVIDER: S-EPMC10150172 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature