Pro-arrhythmic effects of gain-of-function potassium channel mutations in the short QT syndrome.

ABSTRACT: The congenital short QT syndrome (SQTS) is a rare condition characterized by abbreviated rate-corrected QT (QTc) intervals on the electrocardiogram and by increased susceptibility to both atrial and ventricular arrhythmias and sudden death. Although mutations to multiple genes have been implicated in the SQTS, evidence of causality is particularly strong for the first three (SQT1-3) variants: these result from gain-of-function mutations in genes that encode K⁺ channel subunits responsible, respectively, for the I_Kr, I_Ks and I_K1 cardiac potassium currents. This article reviews evidence for the impact of SQT1-3 missense potassium channel gene mutations on the electrophysiological properties of I_Kr, I_Ks and I_K1 and o

SUBMITTER: Hancox JC 

PROVIDER: S-EPMC10150212 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature