Feedback contributions to excitation-contraction coupling in native functioning striated muscle.

ABSTRACT: Skeletal and cardiac muscle excitation-contraction coupling commences with Na_v1.4/Na_v1.5-mediated, surface and transverse (T-) tubular, action potential generation. This initiates feedforward, allosteric or Ca²⁺-mediated, T-sarcoplasmic reticular (SR) junctional, voltage sensor-Cav1.1/Cav1.2 and ryanodine receptor-RyR1/RyR2 interaction. We review recent structural, physiological and translational studies on possible feedback actions of the resulting SR Ca²⁺ release on Na_v1.4/Na_v1.5 function in native muscle. Finite-element modelling predicted potentially regulatory T-SR junctional [Ca²⁺]_TSR domains. Na_v1.4/Na_v1.5, III-IV linker and C-terminal domain structures include

SUBMITTER: Salvage SC 

PROVIDER: S-EPMC10150225 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature