BRD9 Degradation Disrupts Ribosome Biogenesis in Multiple Myeloma.

ABSTRACT:

Purpose

BRD9 is a defining component of the noncanonical SWI/SNF complex, which regulates gene expression by controlling chromatin dynamics. Although recent studies have found an oncogenic role for BRD9 in multiple cancer types including multiple myeloma, its clinical significance and oncogenic mechanism have not yet been elucidated. Here, we sought to identify the clinical and biological impact of BRD9 in multiple myeloma, which may contribute to the development of novel therapeutic strategies.

Experimental design

We performed integrated analyses of BRD9 in vitro and in vivo using multiple myeloma cell lines and primary multiple myeloma cells in established preclinical models, which identified the molecular functions of BRD9 contributing to multiple myeloma cell survival.

SUBMITTER: Kurata K 

PROVIDER: S-EPMC10150249 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature