The protein disulfide isomerase inhibitor 3-methyltoxoflavin inhibits Chikungunya virus.

ABSTRACT: Chikungunya virus (CHIKV) is the etiological agent of chikungunya fever, a (re)emerging arbovirus infection, that causes severe and often persistent arthritis, as well as representing a serious health concern worldwide for which no antivirals are currently available. Despite efforts over the last decade to identify and optimize new inhibitors or to reposition existing drugs, no compound has progressed to clinical trials for CHIKV and current prophylaxis is based on vector control, which has shown limited success in containing the virus. Our efforts to rectify this situation were initiated by screening 36 compounds using a replicon system and ultimately identified the natural product derivative 3-methyltoxoflavin with activity against CHIKV using a cell-based assay (EC₅₀ 200 nM,

SUBMITTER: Puhl AC 

PROVIDER: S-EPMC10150329 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature