Clinical utility of polygenic risk scores for coronary artery disease.

ABSTRACT: Over the past decade, substantial progress has been made in the discovery of alleles contributing to the risk of coronary artery disease. In addition to providing causal insights into disease, these endeavours have yielded and enabled the refinement of polygenic risk scores. These scores can be used to predict incident coronary artery disease in multiple cohorts and indicate the clinical response to some preventive therapies in post hoc analyses of clinical trials. These observations and the widespread ability to calculate polygenic risk scores from direct-to-consumer and health-care-associated biobanks have raised many questions about responsible clinical adoption. In this Review, we describe technical and downstream considerations for the derivation and validation of polygenic risk score

SUBMITTER: Klarin D 

PROVIDER: S-EPMC10150334 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature