Design and characterization of chimeric Rabies-SARS-CoV-2 virus-like particles for vaccine purposes.

ABSTRACT: Due to the high number of doses required to achieve adequate coverage in the context of COVID-19 pandemics, there is a great need for novel vaccine developments. In this field, there have been research approaches that focused on the production of SARS-CoV-2 virus-like particles. These are promising vaccine candidates as their structure is similar to that of native virions but they lack the genome, constituting a biosafe alternative. In order to produce these structures using mammal cells, it has been established that all four structural proteins must be expressed. Here we report the generation and characterization of a novel chimeric virus-like particle (VLP) that can be produced by the expression of a single novel fusion protein that contains SARS-CoV-2 spike (S) ectodomain fused to rabie

SUBMITTER: Garay E 

PROVIDER: S-EPMC10150342 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature