Clinical characteristics and microbiota analysis of 44 patients with granulomatous mastitis.

ABSTRACT:

Introduction

Granulomatous mastitis (GM) is a chronic inflammatory breast disease. In recent years, the role of Corynebacterium in GM onset has received more and more attention. This study aims to detect the dominant bacterium in GM patients and analyze the association between clinical characteristics and infectious factors.

Methods

In this study, 88 samples from 44 GM patients, six acute lactation mastitis (ALM) patients, and 25 non-inflammatory breast disease (NIB) patients were divided into a GM pus group, a GM tissue group, an ALM pus group, and a NIB tissue group; then, 16S ribosomal DNA sequencing was used to explore their microbiota. The clinical data of all 44 GM patients were also retrospectively collected and analyzed to determine their relationship with inf

SUBMITTER: Chen W 

PROVIDER: S-EPMC10150378 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature