Locally Applied Simvastatin as an Adjunct to Promote Spinal Fusion in Rats.

ABSTRACT:

Study design

Basic Science.

Objective

To determine if locally delivered simvastatin can enhance bone formation in a rat spinal fusion model.

Summary of background data

The bone-anabolic properties of statins in fracture healing are well established, however, few studies have evaluated the impact of locally delivered statins in spinal fusion.

Methods

We formulated poly(lactic-co-glycolic acid) (PLGA) nanoparticles by adapting previously published techniques. Two types of nanoparticles were created: simvastatin nanoparticles (SimNP) and nanoparticles without simvastatin (BlankNP). Drug elution from SimNP was characterized. Osteoblastic differentiation was analyzed using MC3T3-E1 cells cultured in differentiation medium containing SimNP or BlankNP. Forty male 12 w

SUBMITTER: Iyer S 

PROVIDER: S-EPMC10150387 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature