The association between baseline circulating progenitor cells and vascular function: The role of aging and risk factors.

ABSTRACT:

Background

To investigate the cross-sectional and longitudinal relationships between vascular function and circulating progenitor cell (CPC) counts with respect to aging and exposure to risk factors.

Methods

In 797 adult participants, CPCs were enumerated by flow cytometry as CD45^med mononuclear cells expressing CD34 epitope and its subsets co-expressing CD133, and chemokine C-X-C motif receptor 4 (CXCR4+). Arterial stiffness was evaluated by tonometry-derived pulse wave velocity (PWV) and microvascular function was assessed as digital reactive hyperemia index (RHI).

Results

In cross-sectional analyses, for every doubling in CD34+ cell counts, PWV was 15% higher and RHI was 9% lower, after adjusting for baseline characteristics and risk factors (p fo

SUBMITTER: Moazzami K 

PROVIDER: S-EPMC10150400 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature