A Salivary Gland Resident Macrophage Subset Regulating Radiation Responses.

ABSTRACT: Radiotherapy of head and neck cancers frequently leads to irreversible hypofunction of salivary glands, which severely compromises the quality of life and is extremely difficult to treat. We found recently that salivary gland resident macrophages are sensitive to radiation and interact with epithelial progenitors and endothelial cells through homeostatic paracrine factors. Heterogeneous subpopulations of resident macrophages are present in other organs with distinct functions, whereas subpopulations of salivary gland resident macrophages with distinct functions or transcriptional profiles have not been reported yet. Using single-cell RNA sequencing, we found that mouse submandibular glands (SMGs) contain 2 distinct self-renewing resident macrophage subsets, an MHC-II^hi subset pr

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC10150438 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature