On the holobiont 'predictome' of immunocompetence in pigs.

ABSTRACT:

Background

Gut microbial composition plays an important role in numerous traits, including immune response. Integration of host genomic information with microbiome data is a natural step in the prediction of complex traits, although methods to optimize this are still largely unexplored. In this paper, we assess the impact of different modelling strategies on the predictive capacity for six porcine immunocompetence traits when both genotype and microbiota data are available.

Methods

We used phenotypic data on six immunity traits and the relative abundance of gut bacterial communities on 400 Duroc pigs that were genotyped for 70 k SNPs. We compared the predictive accuracy, defined as the correlation between predicted and observed phenotypes, of a wide catalogue of models: repr

SUBMITTER: Calle-Garcia J 

PROVIDER: S-EPMC10150480 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature