Liquid-liquid phase separation throws novel insights into treatment strategies for skin cutaneous melanoma.

ABSTRACT:

Background

In recent years, there has been growing evidence indicating a relationship between liquid-liquid phase separation (LLPS) and cancer development. However, to date, the clinical significance of LLPS in skin cutaneous melanoma (SKCM, hereafter referred to as melanoma) remains to be elucidated. In the current study, the impact of LLPS-related genes on melanoma prognosis has been explored.

Methods

LLPS-related genes were retrieved from the DrLLPS database. The prognostic feature for LLPS in melanoma was developed in The Cancer Genome Atlas (TCGA) dataset and verified in the GSE65904 cohort. Based on risk scores, melanoma patients were categorized into high- and low-risk groups. Thereafter, the differences in clinicopathological correlation, functional enrichment, immun

SUBMITTER: Liu J 

PROVIDER: S-EPMC10150491 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature