Caloric restriction remodels the hepatic chromatin landscape and bile acid metabolism by modulating the gut microbiota.

ABSTRACT:

Background

Caloric restriction (CR) has been known to promote health by reprogramming metabolism, yet little is known about how the epigenome and microbiome respond during metabolic adaptation to CR.

Results

We investigate chromatin modifications, gene expression, as well as alterations in microbiota in a CR mouse model. Collectively, short-term CR leads to altered gut microbial diversity and bile acid metabolism, improving energy expenditure. CR remodels the hepatic enhancer landscape at genomic loci that are enriched for binding sites for signal-responsive transcription factors, including HNF4α. These alterations reflect a dramatic reprogramming of the liver transcriptional network, including genes involved in bile acid metabolism. Transferring CR gut microbiota into mice

SUBMITTER: Fan Y 

PROVIDER: S-EPMC10150505 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature