Esculetin releases maturation arrest and induces terminal differentiation in leukemic blast cells by altering the Wnt signaling axes.

ABSTRACT:

Background

The "Differentiation therapy" has been emerging as a promising and more effective strategy against acute leukemia relapses.

Objective

In extension to the revolutionising therapeutic outcomes of All Trans Retinoic Acid (ATRA) to induce terminal differentiation of Acute Promyelocytic Leukemic (APL) blast cells, we decipher the potential effect of a natural compound "Esculetin" to serve as a differentiating agent in Acute Myeloid Leukemia (AML). Underlaying role of Wnt signaling pathways in esculetin mediated blast cell differentiation was also evaluated.

Methods

Human acute myeloid leukemic cells (Kasumi-1) with t(8;21/AML-ETO) translocation were used as a model system. Growth inhibitory and cytotoxic activity of esculetin were analysed using growth kinetics

SUBMITTER: Mathur A 

PROVIDER: S-EPMC10150528 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature