Developing four cuproptosis-related lncRNAs signature to predict prognosis and immune activity in ovarian cancer.

ABSTRACT:

Background

There has been a recent discovery of a new type of cell death produced by copper-iron ions, called Cuproptosis (copper death). The purpose of this study was to identify LncRNA signatures associated with Cuproptosis in ovarian cancer that could be used as prognostic indicators.

Methods

RNA sequencing (RNA-seq) profiles with clinicopathological data from TCGA database were used to select prognostic CRLs and then constructed prognostic risk model using multivariate regression analysis and LASSO algorithms. An independent dataset from GEO database was used to validate the prognostic performance. Combined with clinical factors, we further constructed a prognostic nomogram. In addition, tumor immune microenvironment, somatic mutation and drug sensitivity were analyzed u

SUBMITTER: Liu L 

PROVIDER: S-EPMC10150549 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature