Dysfunctional Cortical Gradient Topography in Treatment-Resistant Major Depressive Disorder.

ABSTRACT:

Background

Treatment-resistant depression (TRD) refers to patients with major depressive disorder who do not remit after 2 or more antidepressant trials. TRD is common and highly debilitating, but its neurobiological basis remains poorly understood. Recent neuroimaging studies have revealed cortical connectivity gradients that dissociate primary sensorimotor areas from higher-order associative cortices. This fundamental topography determines cortical information flow and is affected by psychiatric disorders. We examined how TRD impacts gradient-based hierarchical cortical organization.

Methods

In this secondary study, we analyzed resting-state functional magnetic resonance imaging data from a mindfulness-based intervention enrolling 56 patients with TRD and 28 healthy contro

SUBMITTER: Pasquini L 

PROVIDER: S-EPMC10150583 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature