Intracranial electrophysiological recordings on a swine model of mesial temporal lobe epilepsy.

ABSTRACT:

Objective

To test the feasibility and reliability of intracranial electrophysiological recordings in an acute status epilepticus model on laboratory swine.

Method

Intrahippocampal injection of kainic acid (KA) was performed on 17 male Bama pigs (Sus scrofa domestica) weighing between 25 and 35 kg. Two stereoelectroencephalography (SEEG) electrodes with a total of 16 channels were implanted bilaterally along the sensorimotor cortex to the hippocampus. Brain electrical activity was recorded 2 h daily for 9-28 days. Three KA dosages were tested to evaluate the quantities capable of evoking status epilepticus. Local field potentials (LFPs) were recorded and compared before and after the KA injection. We quantified the epileptic patterns, including the interictal spikes, s

SUBMITTER: Zhu F 

PROVIDER: S-EPMC10150775 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature