β- and γ-C(sp³ )-H Heteroarylation of Free Carboxylic Acids: A Modular Synthetic Platform for Diverse Quaternary Carbon Centers.

ABSTRACT: Pd^II -catalyzed C(sp³ )-H activation of free carboxylic acids represents a significant advance from conventional cyclopalladation initiated reactions. However, developing a modular synthetic platform for diverse quaternary and tertiary carbon centers based on this reactivity, two challenges remain to be addressed: mono-selectivity in each consecutive C-H functionalization step; compatibility with heteroatoms. While the exclusive mono-selectivity was achieved by β-lactonization/nucleophilic attack, the latter limitation remains to be overcome. Herein, we report the Pd^II -catalyzed β- and γ-C(sp³ )-H heteroarylation of free carboxylic acids using pyridine-pyridone ligands capable of overcoming these limitations. A sequence of three consecutive C(sp

SUBMITTER: Meng G 

PROVIDER: S-EPMC10150778 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature