Advanced age is associated with changes in alveolar macrophages and their responses to the stress of traumatic injury.

ABSTRACT: Alveolar macrophages (AMs) are tissue-resident cells of the lower airways that perform many homeostatic functions critical for pulmonary health and protection against pathogens. However, little is known about the factors that shape AMs during healthy aging. In these studies, we sought to characterize age-related changes in AM phenotype, function, and responses to a physiologic stressor, that is, distal injury. Age was associated with a wide range of changes in cell surface receptor and gene expression by AMs, reflecting a unique alternatively activated phenotype. AMs from aged mice also exhibited markers of cellular senescence along with down-regulation of genes involved in growth and cell cycle pathways relative to young controls. Furthermore, AMs from aged mice showed a stunted transcrip

SUBMITTER: Boe DM 

PROVIDER: S-EPMC10150914 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature