Mismatched donor cell infusion-related syndrome following microtransplant in patients with acute myeloid leukemia.

ABSTRACT:

Background

Immunotherapies such as adoptive immune cell infusion and immune-modulating agents are widely used for cancer treatment, and the concomitant symptoms, including cytokine release syndrome (CRS) or immune-related adverse events (irAEs), are frequently reported. However, clinical manifestations induced by mismatched donor granulocyte colony-stimulating factor mobilized peripheral blood mononuclear cell (GPBMC) infusion in patients receiving microtransplant (MST) have not yet been well depicted.

Methods

We analyzed 88 cycles of mismatched GPBMC infusion in patients with acute myeloid leukemia receiving MST and 54 cycles of chemotherapy without GPBMC infusion as a comparison. Clinical symptoms and their correlation with clinical features, laboratory findings, and clini

SUBMITTER: Cai B 

PROVIDER: S-EPMC10150921 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature