The circle of reentry: Characteristics of trigger-substrate interaction leading to sudden cardiac arrest.

ABSTRACT: Sudden cardiac death is often caused by ventricular arrhythmias driven by reentry. Comprehensive characterization of the potential triggers and substrate in survivors of sudden cardiac arrest has provided insights into the trigger-substrate interaction leading to reentry. Previously, a "Triangle of Arrhythmogenesis", reflecting interactions between substrate, trigger and modulating factors, has been proposed to reason about arrhythmia initiation. Here, we expand upon this concept by separating the trigger and substrate characteristics in their spatial and temporal components. This yields four key elements that are required for the initiation of reentry: local dispersion of excitability (e.g., the presence of steep repolarization time gradients), a critical relative size of the region of ex

SUBMITTER: Cluitmans MJM 

PROVIDER: S-EPMC10150924 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature