Cerebrospinal fluid immunoglobulins in primary progressive multiple sclerosis are pathogenic.

ABSTRACT: Multiple sclerosis is clinically characterized by relapses and remissions (relapsing-remitting multiple sclerosis) that over time may evolve to a progressive course (secondary progressive multiple sclerosis) or as having a progressive course from disease onset (primary progressive multiple sclerosis). At present, it is not definitively known whether these clinical entities constitute a single pathological disease or whether these manifestations represent two distinct disease entities sharing inflammatory demyelination as a pathological feature. Here we show using a novel mouse model that CSF of primary progressive multiple sclerosis patients is unique in its capacity to induce motor disability and spinal cord pathology including demyelination, impaired remyelination, reactive astrogliosis

SUBMITTER: Wong JK 

PROVIDER: S-EPMC10151187 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature