Anti-pan-neurofascin antibodies induce subclass-related complement activation and nodo-paranodal damage.

ABSTRACT: Autoimmune neuropathy associated with antibodies against pan-neurofascin is a new subtype of nodo-paranodopathy. It is relevant because it is associated with high morbidity and mortality. Affected patients often require intensive care unit treatment for several months, and data on the reversibility and long-term prognosis are limited. The pathogenicity including IgG subclass-associated mechanisms has not been unravelled, nor directly compared to anti-neurofascin-155 IgG4-related pathology. Understanding the underlying pathology might have a direct impact on treatment of these severely affected patients. By a multicentre combined prospective and retrospective approach, we provide clinical data of a large cohort of patients with anti-neurofascin-associated neuropathy (n = 18) including longi

SUBMITTER: Appeltshauser L 

PROVIDER: S-EPMC10151189 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature