Educational attainment, structural brain reserve and Alzheimer's disease: a Mendelian randomization analysis.

ABSTRACT: Higher educational attainment is observationally associated with lower risk of Alzheimer's disease. However, the biological mechanisms underpinning this association remain unclear. The protective effect of education on Alzheimer's disease may be mediated via increased brain reserve. We used two-sample Mendelian randomization to explore putative causal relationships between educational attainment, structural brain reserve as proxied by MRI phenotypes and Alzheimer's disease. Summary statistics were obtained from genome-wide association studies of educational attainment (n = 1 131 881), late-onset Alzheimer's disease (35 274 cases, 59 163 controls) and 15 measures of grey or white matter macro- or micro-structure derived from structural or diffusion MRI (nmax = 33 211). We conducted univaria

SUBMITTER: Seyedsalehi A 

PROVIDER: S-EPMC10151197 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature