Comprehensive Phenotypic Characterization of Late Gadolinium Enhancement Predicts Sudden Cardiac Death in Coronary Artery Disease.

ABSTRACT:

Background

Late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) offers the potential to noninvasively characterize the phenotypic substrate for sudden cardiac death (SCD).

Objectives

The authors assessed the utility of infarct characterization by CMR, including scar microstructure analysis, to predict SCD in patients with coronary artery disease (CAD).

Methods

Patients with stable CAD were prospectively recruited into a CMR registry. LGE quantification of core infarction and the peri-infarct zone (PIZ) was performed alongside computational image analysis to extract morphologic and texture scar microstructure features. The primary outcome was SCD or aborted SCD.

Results

Of 437 patients (mean age: 64 years; mean left ventricular ejection fraction [L

SUBMITTER: Jones RE 

PROVIDER: S-EPMC10151254 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature