Common gene signatures and molecular mechanisms of diabetic nephropathy and metabolic syndrome.

ABSTRACT:

Background

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. Multiple metabolic toxicities, redox stress, and endothelial dysfunction contribute to the development of diabetic glomerulosclerosis and DN. Metabolic syndrome (MetS) is a pathological state in which the body's ability to process carbohydrates, fats, and proteins is compromised because of metabolic disorders, resulting in redox stress and renal remodeling. However, a causal relationship between MetS and DN has not been proven. This study aimed to provide valuable information for the clinical diagnosis and treatment of MetS with DN.

Methods

Here, transcriptome data of DN and MetS patients were obtained from the Gene Expression Omnibus database, and seven potential biomarkers were screened u

SUBMITTER: Zhang C 

PROVIDER: S-EPMC10151256 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature