Neurite outgrowth induced by stimulation of angiotensin II AT₂ receptors in SH-SY5Y neuroblastoma cells involves c-Src activation.

ABSTRACT: Neuroblastoma, the most common extracranial solid tumor occurring in childhood, originates from the aberrant proliferation of neural crest cells. Accordingly, the mechanism underling neuronal differentiation could provide new strategies for neuroblastoma treatment. It is well known that neurite outgrowth could be induced by Angiotensin II (Ang II) AT₂ receptors; however, the signaling mechanism and its possible interaction with NGF (neural growth factor) receptors remain unclear. Here, we show that Ang II and CGP42112A (AT₂ receptor agonist) promote neuronal differentiation by inducing neurite outgrowth and βIII-tubulin expression in SH-SY5Y neuroblastoma cells. In addition, we demonstrate that treatment with PD123319 (AT₂ receptor antagonist) reverts Ang I

SUBMITTER: Blanco HM 

PROVIDER: S-EPMC10151373 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature