A targeted genetic modifier screen in Drosophila uncovers vulnerabilities in a genetically complex model of colon cancer.

ABSTRACT: Received on 16 January 2023; accepted on 21 February 2023Kinases are key regulators of cellular signal transduction pathways. Many diseases, including cancer, are associated with global alterations in protein phosphorylation networks. As a result, kinases are frequent targets of drug discovery efforts. However, target identification and assessment, a critical step in targeted drug discovery that involves identifying essential genetic mediators of disease phenotypes, can be challenging in complex, heterogeneous diseases like cancer, where multiple concurrent genomic alterations are common. Drosophila is a particularly useful genetic model system to identify novel regulators of biological processes through unbiased genetic screens. Here, we report 2 classic genetic modifier screens focusing

SUBMITTER: Datta I 

PROVIDER: S-EPMC10151408 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature