Fear circuit-based neurobehavioral signatures mirror resilience to chronic social stress in mouse.

ABSTRACT: Consistent evidence from human data points to successful threat-safety discrimination and responsiveness to extinction of fear memories as key characteristics of resilient individuals. To promote valid cross-species approaches for the identification of resilience mechanisms, we establish a translationally informed mouse model enabling the stratification of mice into three phenotypic subgroups following chronic social defeat stress, based on their individual ability for threat-safety discrimination and conditioned learning: the Discriminating-avoiders, characterized by successful social threat-safety discrimination and extinction of social aversive memories; the Indiscriminate-avoiders, showing aversive response generalization and resistance to extinction, in line with finding

SUBMITTER: Ayash S 

PROVIDER: S-EPMC10151471 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature