The temporal and contextual stability of activity levels in hippocampal CA1 cells.

ABSTRACT: Recent long-term optical imaging studies have demonstrated that the activity levels of hippocampal neurons in a familiar environment change on a daily to weekly basis. However, it is unclear whether there is any time-invariant property in the cells' neural representations. In this study, using miniature fluorescence microscopy, we measured the neural activity of the mouse hippocampus in four different environments every 3 d. Although the activity level of hippocampal neurons fluctuated greatly in each environment across days, we found a significant correlation between the activity levels for different days, and the correlation was higher for averaged activity levels across multiple environments. When the number of environments used for averaging was increased, a higher activity correlation

SUBMITTER: Hayashi Y 

PROVIDER: S-EPMC10151562 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature