Plasma levels of VIP are not elevated during PACAP- and VIP-induced cluster headache attacks: an exploratory study.

ABSTRACT:

Background

Pituitary adenylate cyclase-activating peptide (PACAP) and vasoactive intestinal peptide (VIP) provoked cluster headache attacks in individuals with episodic cluster headache during their active phase and individuals with chronic cluster headache. In this study, we investigated whether infusions of PACAP and VIP caused alterations in plasma levels of VIP and their potential contribution to induced cluster headache attacks.

Methods

Participants received either PACAP or VIP infusion for 20 min on 2 separate days with an interval of at least 7 days in between. Blood collection was performed at T₀, T₂₀, T₃₀, and T₉₀. Plasma levels of VIP were measured using a validated radioimmunoassay method.

Results

Blood samples we

SUBMITTER: Deligianni C 

PROVIDER: S-EPMC10151752 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature